A patient of Indian ancestry was among those who received a “miracle” cure from a cancer treatment being tested by a research centre, attaining an unprecedented healing rate when all 14 patients in the experiment had their malignancies vanish.
Nisha Varughese described the immunotherapy drug’s success in treating her as “a miracle.” “The rectal cancer suddenly vanished after immunotherapy — without the need for the standard treatments of radiation, surgery, or chemotherapy — and the cancer has not returned in any of the patients, who have been cancer-free for up to two years,” according to the Memorial Sloan Kettering (MSK) Cancer Centre in New York.
This was the first time, according to researchers, that all of the patients in a cancer trial were entirely healed with a drug and did not have any major side effects.
The trial’s findings were published in the New England Journal of Medicine over the weekend, and they were also presented at an American Society of Clinical Oncology meeting.
It was dubbed “an early glimpse of a significant treatment shift” in an editorial in the Journal.
“Immunotherapy” uses the body’s own immune system as an ally in the fight against cancer, according to MSK.
“Immune cells have a checkpoint that prevents them from targeting normal cells,” it stated. Cancer cells can disable immune cells, allowing tumours to hide and grow.
She explained that immunotherapy employs a “checkpoint inhibitor,” which allows immune cells to recognise and target cancer cells.
Varughese described the moment she realised she was cancer-free: I didn’t see the tumour that day. So, I wondered, where is the tumour? Then it occurred to me that it could be hidden someplace inside. There is no longer a tumour, according to the doctor. It’s kind of Miracle for me.
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The immunotherapy shrunk the tumours far faster than I expected, said Andrea Cercek, a cancer doctor who led the trial.
It’s incredibly exciting, said Luis Diaz, who was the other researcher leading the trial and is a member of the White House National Cancer Advisory Board. This is, in my opinion, a huge step forward for patients.
Chemotherapy, radiation, and surgery are usually used to treat rectal cancer. The most intriguing thing, according to Cercek, is that each of our patients simply required immunotherapy. We haven’t exposed anyone to radiation, and we haven’t subjected anyone to surgery.
A cancer researcher from the University of North Carolina, Hanna K Sanoff, noted in the Journal editorial, “Whether the outcomes of this small trial undertaken at the MSK Cancer Centre will be generalisable to a broader group of patients with rectal cancer is unclear.”
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